Temporal-thalamic and cingulo-opercular connectivity in people with schizophrenia.

ABSTRACT: A growing body of research has suggested that people with schizophrenia (SZ) exhibit altered patterns of functional and anatomical brain connectivity. For example, many previous resting state functional connectivity (rsFC) studies have shown that, compared to healthy controls (HC), people with SZ demonstrate hyperconnectivity between subregions of the thalamus and sensory cortices, as well as hypoconnectivity between subregions of the thalamus and prefrontal cortex. In addition to thalamic findings, hypoconnectivity between cingulo-opercular brain regions thought to be involved in salience detection has also been commonly reported in people with SZ. However, previous studies have largely relied on seed-based analyses. Seed-based approaches require researchers to define a single a priori br

SUBMITTER: Culbreth AJ 

PROVIDER: S-EPMC7750447 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature