Quantitative Multi-Parameter Mapping Optimized for the Clinical Routine.

ABSTRACT: Using quantitative multi-parameter mapping (MPM), studies can investigate clinically relevant microstructural changes with high reliability over time and across subjects and sites. However, long acquisition times (20 min for the standard 1-mm isotropic protocol) limit its translational potential. This study aimed to evaluate the sensitivity gain of a fast 1.6-mm isotropic MPM protocol including post-processing optimized for longitudinal clinical studies. 6 healthy volunteers (35±7 years old; 3 female) were scanned at 3T to acquire the following whole-brain MPM maps with 1.6 mm isotropic resolution: proton density (PD), magnetization transfer saturation (MT), longitudinal relaxation rate (R1), and transverse relaxation rate (R2^*). MPM maps were generated using two RF transmit fie

SUBMITTER: Cooper G 

PROVIDER: S-EPMC7750476 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature