Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.

ABSTRACT: Tumor-associated macrophages (TAMs) can have protumor properties, including suppressing immune responses, promoting vascularization and, consequently, augmenting tumor progression. To stop TAM-mediated immunosuppression, we use a novel treatment by injecting antibodies specific for scavenger receptor MARCO, which is expressed on a specific subpopulation of TAMs in the tumor. We now report the location of this TAM as well as the pleiotropic mechanism of action of anti-MARCO antibody treatment on tumor progression and further show that this is potentially relevant to humans. Using specific targeting, we observed decreased tumor vascularization, a switch in the metabolic program of MARCO-expressing macrophages, and activation of natural killer (NK) cell killing through TNF-related apoptosis-i

SUBMITTER: Eisinger S 

PROVIDER: S-EPMC7750482 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature