M⁵C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer.

ABSTRACT: 5-Methylcytosine (m⁵C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer. The function of m⁵C is modulated by regulatory proteins, including methyltransferases (writers) and special binding proteins (readers). This study aims at comprehensive study of the m⁵C RNA methylation-related genes and the main pathways under m⁵C RNA methylation in gastrointestinal (GI) cancer. Our result showed that the expression of m⁵C writers and reader was mostly up-regulated in GI cancer. The NSUN2 gene has the highest proportion of mutations found in GI cancer. Importantly, in liver cancer, higher expression

SUBMITTER: Xiang S 

PROVIDER: S-EPMC7750483 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature