Comparison of Manual and Semi-Automatic [¹⁸F]PSMA-1007 PET Based Contouring Techniques for Intraprostatic Tumor Delineation in Patients With Primary Prostate Cancer and Validation With Histopathology as Standard of Reference.

ABSTRACT:

Purpose

Accurate contouring of intraprostatic gross tumor volume (GTV) is pivotal for successful delivery of focal therapies and for biopsy guidance in patients with primary prostate cancer (PCa). Contouring of GTVs, using 18-Fluor labeled tracer prostate specific membrane antigen positron emission tomography ([¹⁸F]PSMA-1007/PET) has not been examined yet.

Patients and methods

Ten Patients with primary PCa who underwent [¹⁸F]PSMA-1007 PET followed by radical prostatectomy were prospectively enrolled. Coregistered histopathological gross tumor volume (GTV-Histo) was used as standard of reference. PSMA-PET images were contoured on two ways: (1) manual contouring with PET scaling SUVmin-max: 0-10 was performed by three teams with different levels of experi

SUBMITTER: Spohn SKB 

PROVIDER: S-EPMC7750498 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature