Integrating Tumor Stroma Biomarkers With Clinical Indicators for Colon Cancer Survival Stratification.

ABSTRACT: The tumor stroma plays an important role in tumor progression and chemotherapeutic resistance; however, its role in colon cancer (CC) survival prognosis remains to be investigated. Here, we identified tumor stroma biomarkers and evaluated their role in CC prognosis stratification. Four independent datasets containing a total of 1,313 patients were included in this study and were divided into training and testing sets. Stromal scores calculated using the estimation of stromal and immune cells in malignant tumors using expression data (ESTIMATE) algorithm were used to assess the tumor stroma level. Kaplan-Meier curves and the log-rank test were used to identify relationships between stromal score and prognosis. Tumor stroma biomarkers were identified by cross-validation of multiple datasets

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7750539 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature