K_V7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells.

ABSTRACT: Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded k_V7 channels have considerable impact on arterial diameter and these channels are known to be expressed in VSMCs but not yet defined in ECs. However, expression of k_V7 channels in ECs would add an extra level of vascular control. This study aims to characterize the expression and function of K_V7 channels within rat mesenteric artery ECs. Experimental Approach: In rat mesenteric artery, KCNQ transcript and K_V7 channel protein expression were determined via RT-qPCR, immunocytochemistry, immunohistochemistry a

SUBMITTER: Baldwin SN 

PROVIDER: S-EPMC7750541 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature