Differences in fungal immune recognition by monocytes and macrophages: N-mannan can be a shield or activator of immune recognition.

ABSTRACT: We designed experiments to assess whether fungal cell wall mannans function as an immune shield or an immune agonist. Fungal cell wall β-(1,3)-glucan normally plays a major and dominant role in immune activation. The outer mannan layer has been variously described as an immune shield, because it has the potential to mask the underlying β-(1,3)-glucan, or an immune activator, as it also has the potential to engage with a wide range of mannose detecting PRRs. To resolve this conundrum we examined species-specific differences in host immune recognition in the och1Δ N-mannosylation-deficient mutant background in four species of yeast-like fungi. Irrespective of the fungal species, the cytokine response (TNFα and IL-6) induced by the och1Δ mutants in human monocytes was red

SUBMITTER: Yadav B 

PROVIDER: S-EPMC7750734 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature