Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals.

ABSTRACT: Cellulose nanocrystals (CNC), also known as nanowhiskers, have recently gained much attention due to their biodegradable nature, advantageous chemical and mechanical properties, economic value and renewability thus making them attractive for a wide range of applications. However, before these materials can be considered for potential uses, investigation of their toxicity is prudent. Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. In this study, we aimed to assess the neoplastic-like transformation potential of two forms of CNC derived from wood (powder and gel) in human pulmonary epithelial cells

SUBMITTER: Kisin ER 

PROVIDER: S-EPMC7750788 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature