Delta-gamma phase-amplitude coupling as a biomarker of postictal generalized EEG suppression.

ABSTRACT: Postictal generalized EEG suppression is the state of suppression of electrical activity at the end of a seizure. Prolongation of this state has been associated with increased risk of sudden unexpected death in epilepsy, making characterization of underlying electrical rhythmic activity during postictal suppression an important step in improving epilepsy treatment. Phase-amplitude coupling in EEG reflects cognitive coding within brain networks and some of those codes highlight epileptic activity; therefore, we hypothesized that there are distinct phase-amplitude coupling features in the postictal suppression state that can provide an improved estimate of this state in the context of patient risk for sudden unexpected death in epilepsy. We used both intracranial and scalp EEG data from elev

SUBMITTER: Grigorovsky V 

PROVIDER: S-EPMC7750942 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature