UniRule: a unified rule resource for automatic annotation in the UniProt Knowledgebase.

ABSTRACT:

Motivation

The number of protein records in the UniProt Knowledgebase (UniProtKB: https://www.uniprot.org) continues to grow rapidly as a result of genome sequencing and the prediction of protein-coding genes. Providing functional annotation for these proteins presents a significant and continuing challenge.

Results

In response to this challenge, UniProt has developed a method of annotation, known as UniRule, based on expertly curated rules, which integrates related systems (RuleBase, HAMAP, PIRSR, PIRNR) developed by the members of the UniProt consortium. UniRule uses protein family signatures from InterPro, combined with taxonomic and other constraints, to select sets of reviewed proteins which have common functional properties supported by experimental evidence. This anno

SUBMITTER: MacDougall A 

PROVIDER: S-EPMC7750954 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature