A Mendelian randomization analysis of circulating lipid traits and breast cancer risk.

ABSTRACT:

Background

Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk, but results have been inconsistent. As Mendelian randomization analyses may provide evidence for causal inference, we sought to evaluate potentially unbiased associations between breast cancer risk and four genetically predicted lipid traits.

Methods

Previous genome-wide association studies (GWAS) have identified 164 discrete variants associated with high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides and total cholesterol. We used 162 of these unique variants to construct weighted genetic scores (wGSs) for a total of 101 424 breast cancer cases and 80 253 controls of European ancestry from the

SUBMITTER: Beeghly-Fadiel A 

PROVIDER: S-EPMC7750975 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature