Genetic risk for Alzheimer's disease influences neuropathology via multiple biological pathways.

ABSTRACT: Alzheimer's disease is a highly heritable, common neurodegenerative disease characterized neuropathologically by the accumulation of β-amyloid plaques and tau-containing neurofibrillary tangles. In addition to the well-established risk associated with the APOE locus, there has been considerable success in identifying additional genetic variants associated with Alzheimer's disease. Major challenges in understanding how genetic risk influences the development of Alzheimer's disease are clinical and neuropathological heterogeneity, and the high level of accompanying comorbidities. We report a multimodal analysis integrating longitudinal clinical and cognitive assessment with neuropathological data collected as part of the Brains for Dementia Research study to understand how genetic ris

SUBMITTER: Hannon E 

PROVIDER: S-EPMC7750986 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature