Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Background

Evidence concerning the potential repurposing of antihypertensives for Alzheimer's disease prevention is inconclusive. We used Mendelian randomization, which can be more robust to confounding by indication and patient characteristics, to investigate the effects of lowering systolic blood pressure, via the protein targets of different antihypertensive drug classes, on Alzheimer's disease.

Methods

We used summary statistics from genome-wide association studies of systolic blood pressure and Alzheimer's disease in a two-sample Mendelian randomization analysis. We identified single-nucleotide polymorphisms (SNPs) that mimic the action of antihypertensive protein targets and estimated the effect of lowering systolic blood pressure on Alzheimer's disease in three ways:

SUBMITTER: Walker VM 

PROVIDER: S-EPMC7751008 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature