Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data.

ABSTRACT:

Summary

Advances in single-cell technologies have enabled the investigation of T-cell phenotypes and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient analysis of these large-scale datasets are instrumental for advancing our understanding of adaptive immune responses. However, while well-established solutions are accessible for the processing of single-cell transcriptomes, no streamlined pipelines are available for the comprehensive characterization of T-cell receptors. Here, we propose single-cell immune repertoires in Python (Scirpy), a scalable Python toolkit that provides simplified access to the analysis and visualization of immune repertoires from single cells and seamless integration with transcriptomic data.

Availability and imple

SUBMITTER: Sturm G 

PROVIDER: S-EPMC7751015 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature