T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II.

ABSTRACT:

Background

Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers and metabolically healthy obesity (MHO) are scarce.

Methods

In this cross-sectional analysis, we included a sample of 437 older participants (60-84 years) from the Berlin Aging Study II (BASE-II). Peripheral blood mononuclear cells were isolated, immune cell subsets were analyzed with multiparameter flow cytometry and systemic cytokine levels were measured. Immune cell parameters were correlated with metabolic measures and multiple linear regression analysis was

SUBMITTER: Sbierski-Kind J 

PROVIDER: S-EPMC7751110 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature