Estimating Transmission Parameters for Respiratory Syncytial Virus and Predicting the Impact of Maternal and Pediatric Vaccination.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a leading cause of respiratory tract illness in young children and a major cause of hospital admissions globally.

Methods

Here we fit age-structured transmission models with immunity propagation to data from the Netherlands (2012-2017). Data included nationwide hospitalizations with confirmed RSV, general practitioner (GP) data on attendance for care from acute respiratory infection, and virological testing of acute respiratory infections at the GP. The transmission models, equipped with key parameter estimates, were used to predict the impact of maternal and pediatric vaccination.

Results

Estimates of the basic reproduction number were generally high (R0 > 10 in scenarios with high statistical support), while susceptibi

SUBMITTER: van Boven M 

PROVIDER: S-EPMC7751153 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature