Effects of dexmedetomidine on immune response in patients undergoing radical and reconstructive surgery for oral cancer.

ABSTRACT: Oral cancer is one of the most common malignancies in the world. The present study aimed to investigate the effects of dexmedetomidine on immune response in patients undergoing radical and reconstructive surgery for oral cancer. Patients were randomly divided into the dexmedetomidine and control groups. Within 15 min before anesthesia induction, dexmedetomidine was infused with a 0.5 µg·kg^-1 loading dose followed by a maintenance dose of 0.4 µg·kg^-1·h^-1 to the end of operation in the dexmedetomidine group, whereas the same volume of saline was administered in the control group. Blood samples were obtained at five time-points: 30 min Before induction (T₀), 1 h after induction (T₁), end of the operation (T₂) and 24 (T₃

SUBMITTER: Huang L 

PROVIDER: S-EPMC7751342 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature