Macrel: antimicrobial peptide screening in genomes and metagenomes.

ABSTRACT:

Motivation

Antimicrobial peptides (AMPs) have the potential to tackle multidrug-resistant pathogens in both clinical and non-clinical contexts. The recent growth in the availability of genomes and metagenomes provides an opportunity for in silico prediction of novel AMP molecules. However, due to the small size of these peptides, standard gene prospection methods cannot be applied in this domain and alternative approaches are necessary. In particular, standard gene prediction methods have low precision for short peptides, and functional classification by homology results in low recall.

Results

Here, we present Macrel (for metagenomic AMP classification and retrieval), which is an end-to-end pipeline for the prospection of high-quality AMP candidates from (meta)genomes. For t

SUBMITTER: Santos-Junior CD 

PROVIDER: S-EPMC7751412 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature