Mutational spectra of SARS-CoV-2 isolated from animals.

ABSTRACT: Coronaviruses are ubiquitous and infect a wide spectrum of animals and humans. The newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a worldwide pandemic. To address the role that animals may play in the evolution of SARS-CoV-2, the full genome sequences of SARS-CoV-2 isolated from animals were compared with SARS-CoV-2 human isolates from the same clade and geographic region. Phylogenetic analysis of SARS-CoV-2 isolated from the cat, dog, mink, mouse, and tiger revealed a close relationship with SARS-CoV-2 human isolates from the same clade and geographic region with sequence identities of 99.94-99.99%. The deduced amino acid sequence of spike (S) protein revealed the presence of a furin cleavage site (⁶⁸²RRAR▾⁶⁸⁵), which did not di

SUBMITTER: Elaswad A 

PROVIDER: S-EPMC7751428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature