Association of Rs61764370 polymorphism within let-7 microRNA-binding site with lung cancer in Iranian population.

ABSTRACT:

Introduction

Polymorphisms within miRNAs binding sites are associated with miRNAs function. The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population.

Methods

This case-control study was conducted with 100 lung cancer patients and 100 healthy persons. The rs61764370 polymorphism was analyzed using PCR-RFLP technique and direct sequencing.

Results

We found a significant relationship between rs61764370 (T / G) polymorphism and lung cancer risk, the GT genotype (OR: 6.25; 95% CI = 2.605-15.00; P= 0.000) and G allele (OR: 5.25; 95% CI = 2.259-12.208; P= 0.000) were significantly associated with an increased risk of lung cancer.

Conclusion

A

SUBMITTER: Farokhzad N 

PROVIDER: S-EPMC7751538 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature