Gender Differences in the First-Year Antipsychotic Treatment for Chinese First-Episode Schizophrenia.

ABSTRACT:

Objective

To investigate the gender differences in the efficacy and side effects of three frequently used antipsychotic medicines (risperidone, olanzapine, aripiprazole) for patients with first-episode schizophrenia during the first year of treatment.

Methods

A total of 569 patients with first-episode schizophrenia were randomly assigned to risperidone, olanzapine, and aripiprazole groups. All patients were treated according to their actual clinical needs. Clinical efficacies were assessed by the Positive and Negative Symptom Scale (PANSS) and side effects were assessed by the Udvalg for Kliniske Undersogelser Side-Effect scale (UKU). All assessments were completed at baseline and at 1, 2, 3, 6, 9, and 12 months.

Results

Males had higher baseline PANSS total scores an

SUBMITTER: Pu C 

PROVIDER: S-EPMC7751687 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature