Ultra Long-Acting β-Agonists in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Introduction

Inhaled β-agonists have been foundational medications for maintenance COPD management for decades. Through activation of cyclic adenosine monophosphate pathways, these agents relax airway smooth muscle and improve expiratory airflow by relieving bronchospasm and alleviating air trapping and dynamic hyperinflation improving breathlessness, exertional capabilities, and quality of life. β-agonist drug development has discovered drugs with increasing longer durations of action: short acting (SABA) (4-6 h), long acting (LABA) (6-12 h), and ultra-long acting (ULABA) (24 h). Three ULABAs, indacaterol, olodaterol, and vilanterol, are approved for clinical treatment of COPD.

Purpose

This article reviews both clinically approved ULABAs and ULABAs in development.

Conclu

SUBMITTER: Burkes RM 

PROVIDER: S-EPMC7751789 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature