Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease.

ABSTRACT:

Background & aims

We investigated the effects of inducing deep remission in patients with early Crohn's disease (CD).

Methods

We collected follow-up data from 122 patients (mean age, 31.2 ± 11.3 y) with early, moderate to severe CD (median duration, 0.2 years; interquartile range, 0.1-0.5) who participated in the Effect of Tight Control Management on CD (CALM) study, at 31 sites, representing 50% of the original CALM patient population. Fifty percent of patients (n = 61) were randomly assigned to a tight control strategy (increased therapy based on fecal level of calprotectin, serum level of C-reactive protein, and symptoms), and 50% were assigned to conventional management. We categorized patients as those who were vs were not in deep remission (CD endoscopic index of sever

SUBMITTER: Ungaro RC 

PROVIDER: S-EPMC7751802 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature