Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies.

ABSTRACT: Since benzo [ b ] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[ b ]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[ b ]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, ¹H NMR and ¹³C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSARbased models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this t

SUBMITTER: Unver Y 

PROVIDER: S-EPMC7751927 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature