In-situ stable injectable collagen-based hydrogels for cell and growth factor delivery.

ABSTRACT: Here we report development of in-situ stable injectable hydrogels for delivery of cells and growth factors based on two precursors, alginate, and collagen/calcium sulfate (CaSO₄). The alg/col hydrogels were shear-thinning, injectable through commercially available needles and stable right after injection. Rheological measurements revealed that pre-crosslinked alg/col hydrogels fully crosslinked at 37°C and that the storage modulus of alg/col hydrogels increased with increasing the collagen content or the concentration of CaSO₄. The viscoelastic characteristics and injectability of the alg/col hydrogels were not significantly impacted by the storage of precursor solutions for 28 days. An osteoinductive bone morphogenic protein-2 (BMP-2) loaded into alg/col hydrogels wa

SUBMITTER: Moeinzadeh S 

PROVIDER: S-EPMC7751945 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature