Assessment of transcriptional importance of cell line-specific features based on GTRD and FANTOM5 data.

ABSTRACT: Creating a complete picture of the regulation of transcription seems to be an urgent task of modern biology. Regulation of transcription is a complex process carried out by transcription factors (TFs) and auxiliary proteins. Over the past decade, ChIP-Seq has become the most common experimental technology studying genome-wide interactions between TFs and DNA. We assessed the transcriptional significance of cell line-specific features using regression analysis of ChIP-Seq datasets from the GTRD database and transcriptional start site (TSS) activities from the FANTOM5 expression atlas. For this purpose, we initially generated a large number of features that were defined as the presence or absence of TFs in different promoter regions around TSSs. Using feature selection and regression analysi

SUBMITTER: Sharipov RN 

PROVIDER: S-EPMC7751965 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature