Fuzzy protein theory for disordered proteins.

ABSTRACT: Why proteins are fuzzy? Constant adaptation to the cellular environment requires a wide range of changes in protein structure and interactions. Conformational ensembles of disordered proteins in particular exhibit large shifts to activate or inhibit alternative pathways. Fuzziness is critical for liquid-liquid phase separation and conversion of biomolecular condensates into fibrils. Interpretation of these phenomena presents a challenge for the classical structure-function paradigm. Here I discuss a multi-valued formalism, based on fuzzy logic, which can be applied to describe complex cellular behavior of proteins.

SUBMITTER: Fuxreiter M 

PROVIDER: S-EPMC7752076 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature