Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.

ABSTRACT: Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cancer based on androgen deprivation therapy (ADT) effectively decreases tumor size, it also causes profound alterations in immune tumor microenvironment within the prostate. Here, we demonstrate that prostates of a mouse model invalidated for nuclear receptors liver X receptors (LXRs), crucial lipid metabolism and inflammation integrators, respond in an unexpected way to androgen deprivation. Indeed, we observed profound alterations in immune cells composition, which was associate

SUBMITTER: Bousset L 

PROVIDER: S-EPMC7752095 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature