Reprogramming to recover youthful epigenetic information and restore vision.

ABSTRACT: Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity^1-3. Changes to DNA methylation patterns over time form the basis of ageing clocks⁴, but whether older individuals retain the information needed to restore these patterns-and, if so, whether this could improve tissue function-is not known. Over time, the central nervous system (CNS) loses function and regenerative capacity^5-7. Using the eye as a model CNS tissue, here we show that ectopic expression of Oct4 (also known as Pou5f1), Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA met

SUBMITTER: Lu Y 

PROVIDER: S-EPMC7752134 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature