Quantitatively monitoring acute ischemic stroke patients post recombinant tissue plasminogen activator treatment.

ABSTRACT:

Background and aims

Thrombolytic therapy is widely used to treat acute ischemic stroke (AIS) patients. As intracerebral hemorrhage is a life-threatening complication of this therapy, monitoring the fibrinolytic and coagulation systems is imperative. However, existing studies on plasmin inhibitor complex (PIC) and thrombin-antithrombin III complex (TAT) mostly apply the enzyme-linked immunosorbent assay (ELISA) method. The aim of this study is to establish the baseline of thrombolytic treatment for AIS patients; to monitor the fibrinolytic and coagulation system following alteplase administration; to ascertain the proper time point to predict intracerebral hemorrhage.

Methods

The method used to assess a patient's intravascular situation, namely chemiluminescence, was used to

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7752160 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature