Proteomic Profiling of Seminal Plasma Proteins in Varicocele Patients.

ABSTRACT:

Purpose

Seminal plasma provides a nutritive and protective milieu for spermatozoa. It contains factors/proteins required for sperm maturation, hyperactivation, capacitation and acrosome reaction. Alteration in the expression levels of seminal plasma proteins affect the fertilization process. The main objective of this study is to compare the seminal plasma proteome of healthy fertile men (control group) with varicocele patients in order to identify the differentially expressed seminal plasma proteins.

Materials and methods

Pooled seminal plasma samples from control (n=5) and varicocele (unilateral: n=5 and bilateral: n=5) subjects were used for proteomic profiling and functional bioinformatic analysis. Key differentially expressed proteins (DEPs) associated with binding of z

SUBMITTER: Panner Selvam MK 

PROVIDER: S-EPMC7752508 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature