Sex-Associated Gene Expression Alterations Correlate With Esophageal Cancer Survival.

ABSTRACT:

Objectives

Esophageal cancer (EC) is a significant cause of cancer death with 5-year survival of 10%-15% and males more frequently affected. Genetic evaluation for loci highlighting risk has been performed, but survival data are limited. The Cancer Genome Atlas (TCGA) data sets allow for potential prognostic marker assessment in large patient cohorts. The study aimed to use the TCGA EC data set to assess whether survival varies by sex and explore genetic alterations that may explain variation observed.

Methods

TCGA clinical/RNA-seq data sets (n = 185, 158 males/27 females) were downloaded from the cancer genome browser. Data analysis/figure preparation was performed in R and GraphPad Prism 7. Survival analysis was performed using the survival package. Text mining of PubMed w

SUBMITTER: Weygant N 

PROVIDER: S-EPMC7752676 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature