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Research progress and perspective in metabolism and metabolomics of psoriasis.

ABSTRACT:

Abstract

Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.

SUBMITTER: Lian N

PROVIDER: S-EPMC7752687 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Research progress and perspective in metabolism and metabolomics of psoriasis.

Lian Ni N Shi Li-Qing LQ Hao Zhi-Min ZM Chen Min M

Chinese medical journal 20201120 24

<h4>Abstract</h4>Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our underst ...[more]

PMID: 33237698

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