¹¹C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

ABSTRACT:

Objective

Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of ¹¹C-UCB-J, a ligand for presynaptic vesicle protein 2A (SV2A), a vesicle membrane protein ubiquitously expressed in synapses.

Methods

We performed ¹¹C-UCB-J PET in two DLB patients (an amyloid-negative male and an amyloid-positive female in their 70s) and 10 similarly aged healthy controls. The DLB subjects also underwent PET imaging of amyloid (¹¹C-PiB) and tau (¹⁸F-AV-1451). ¹¹C-UCB-J binding was quantified using non-displaceable binding pot

SUBMITTER: Nicastro N 

PROVIDER: S-EPMC7752786 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature