Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD.

ABSTRACT:

Rationale & objectives

Adiposity and physical fitness levels are major drivers of cardiometabolic risk, but these relationships have not been well-characterized in chronic kidney disease (CKD). We examined the associations of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intrahepatic fat, and physical function with inflammation, insulin resistance, and adipokine levels in patients with CKD.

Study design

Prospective cohort study.

Setting & participants

Participants with stages 3-5 CKD not receiving maintenance dialysis, followed up at one of 8 clinical sites in the Chronic Renal Insufficiency Cohort (CRIC) Study, and who underwent magnetic resonance imaging of the abdomen at an annual CRIC Study visit (n = 419).

Predictors

VAT volume, SAT vol

SUBMITTER: Navaneethan SD 

PROVIDER: S-EPMC7752817 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature