Treating Home Versus Predialysis Blood Pressure Among In-Center Hemodialysis Patients: A Pilot Randomized Trial.

ABSTRACT:

Rationale & objective

Observational studies have reported a U-shaped association between blood pressure (BP) before a hemodialysis session and death. In contrast, because a linear association between out-of-dialysis-unit BP and death has been reported, home BP may be a better target for treatment. To test the feasibility of this approach, we conducted a pilot trial of treating home versus predialysis BP in hemodialysis patients.

Study design

A 4-month, parallel, randomized, controlled trial.

Settings & participants

50 prevalent hemodialysis patients in San Francisco and Seattle. Participants were randomly assigned using 1:1 block randomization, stratified by site.

Interventions

To target home systolic BP (SBP) of 100-<140 mm Hg versus predialysis SBP of 100-<14

SUBMITTER: Bansal N 

PROVIDER: S-EPMC7752836 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature