Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates.

ABSTRACT: Emerging evidence suggests that atrial fibrillation is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear. In this cross-sectional analysis from the Swiss-atrial fibrillation Study (NCT02105844), we investigated the association of serum neurofilament light protein, a neuronal injury biomarker, with (i) the CHA₂DS₂-VASc score (congestive heart failure, hypertension, age 65-74 or >75 years, diabetes mellitus, stroke or transient ischaemic attack, vascular disease, sex), clinical and neuroimaging parameters and (ii) cognitive measures in atrial fibrillation patients. We measured neurofilament light in serum using an ultrasensitive single-molecule array assay in a sample of 1379 atrial fibrillation patients (mean ag

SUBMITTER: Polymeris AA 

PROVIDER: S-EPMC7753055 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature