How handling extreme C-reactive protein (CRP) values and regularization influences CRP and depression criteria associations in network analyses.

ABSTRACT: Increasingly, it has been recognized that analysis at the symptom, rather than diagnostic, level will drive progress in the field of immunopsychiatry. Network analysis offers a useful tool in this pursuit with the ability to identify associations between immune markers and individual symptoms, independent of all other variables modeled. However, investigation into how methodological decisions (i.e., including vs. excluding participants with C-reactive protein (CRP) >10 mg/L, regularized vs. nonregularized networks) influence results is necessary to establish best practices for the use of network analysis in immunopsychiatry. In a sample of 3,464 adult participants from the 2015-2016 National Health and Nutrition Examination Survey dataset, this study found consistent support for associatio

SUBMITTER: Moriarity DP 

PROVIDER: S-EPMC7753060 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature