Epigenetic Variation Analysis Leads to Biomarker Discovery in Gastric Adenocarcinoma.

ABSTRACT: As one of the most common malignant tumors worldwide, gastric adenocarcinoma (GC) and its prognosis are still poorly understood. Various genetic and epigenetic factors have been indicated in GC carcinogenesis. However, a comprehensive and in-depth investigation of epigenetic alteration in gastric cancer is still missing. In this study, we systematically investigated some key epigenetic features in GC, including DNA methylation and five core histone modifications. Data from The Cancer Genome Atlas Program and other studies (Gene Expression Omnibus) were collected, analyzed, and validated with multivariate statistical analysis methods. The landscape of epi-modifications in gastric cancer was described. Chromatin state transition analysis showed a histone marker shift in gastric cancer genome

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7753064 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature