Identification of Hub Prognosis-Associated Oxidative Stress Genes in Pancreatic Cancer Using Integrated Bioinformatics Analysis.

ABSTRACT:

Background

Intratumoral oxidative stress (OS) has been associated with the progression of various tumors. However, OS has not been considered a candidate therapeutic target for pancreatic cancer (PC) owing to the lack of validated biomarkers.

Methods

We compared gene expression profiles of PC samples and the transcriptome data of normal pancreas tissues from The Cancer Genome Atlas (TCGA) and Genome Tissue Expression (GTEx) databases to identify differentially expressed OS genes in PC. PC patients' gene profile from the Gene Expression Omnibus (GEO) database was used as a validation cohort.

Results

A total of 148 differentially expressed OS-related genes in PC were used to construct a protein-protein interaction network. Univariate Cox regression analysis, least absol

SUBMITTER: Qiu X 

PROVIDER: S-EPMC7753072 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature