Silver-catalyzed synthesis of β-fluorovinylphosphonates by phosphonofluorination of aromatic alkynes.

ABSTRACT: A silver-catalyzed three-component reaction involving alkynes, Selectfluor^®, and diethyl phosphite was employed for the one-pot formation of C(sp²)-F and C(sp²)-P bonds to provide an efficient access to β-fluorovinylphosphonates in a highly regio- and stereoselective manner under mild reaction conditions. This reaction is operationally simple and offers an excellent functional group tolerance as well as a broad substrate scope that includes both terminal and internal alkynes. The reaction proceeded through the oxidative generation of a P-centered radical and subsequent fluorine atom transfer.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7753110 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature