Miro1-mediated mitochondrial positioning supports subcellular redox status.

ABSTRACT: Mitochondria are strategically trafficked throughout the cell by the action of microtubule motors, the actin cytoskeleton and adapter proteins. The intracellular positioning of mitochondria supports subcellular levels of ATP, Ca²⁺ and reactive oxygen species (ROS, i.e. hydrogen peroxide, H₂O₂). Previous work from our group showed that deletion of the mitochondrial adapter protein Miro1 leads to perinuclear clustering of mitochondria, leaving the cell periphery devoid of mitochondria which compromises peripheral energy status. Herein, we report that deletion of Miro1 significantly restricts subcellular H₂O₂ levels to the perinuclear space which directly affects intracellular responses to elevated mitochondrial ROS. Using the genetically

SUBMITTER: Alshaabi H 

PROVIDER: S-EPMC7753203 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature