Therapeutic advances of miRNAs: A preclinical and clinical update.

ABSTRACT: miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

SUBMITTER: Chakraborty C 

PROVIDER: S-EPMC7753224 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature