Increased susceptibility to SARS-CoV-2 infection in patients with reduced left ventricular ejection fraction.

ABSTRACT:

Aims

Cardiovascular disease has been recognized as a major determinant of coronavirus disease 2019 (COVID-19) vulnerability and severity. Angiotensin-converting enzyme (ACE) 2 is a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is up-regulated in patients with heart failure. We sought to examine the potential association between reduced left ventricular ejection fraction (LVEF) and the susceptibility to SARS-CoV-2 infection.

Methods and results

Of the 1162 patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention between February 2014 and October 2018, we enrolled 889 patients with available clinical follow-up data. Follow-up was conducted by telephone interviews 1 month after the start of the Frenc

SUBMITTER: Matsushita K 

PROVIDER: S-EPMC7753539 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature