Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism.

ABSTRACT: Microglia are brain immune cells responsible for immune surveillance. Microglial activation is, however, closely associated with neuroinflammation, neurodegeneration, and obesity. Therefore, it is critical that microglial immune response appropriately adapts to different stressors. The circadian clock controls the cellular process that involves the regulation of inflammation and energy hemostasis. Here, we observed a significant circadian variation in the expression of markers related to inflammation, nutrient utilization, and antioxidation in microglial cells isolated from mice. Furthermore, we found that the core clock gene-Brain and Muscle Arnt-like 1 (Bmal1) plays a role in regulating microglial immune function in mice and microglial BV-2 cells by using quantitative RT-PCR. B

SUBMITTER: Wang XL 

PROVIDER: S-EPMC7753637 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature