CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction.

ABSTRACT: Myocardial infarction (MI) results in cardiomyocyte death and ultimately leads to heart failure. Pyroptosis is a type of the inflammatory programmed cell death that has been found in various diseased tissues. However, the role of pyroptosis in MI heart remains unknown. Here, we showed that CXADR-like membrane protein (CLMP) was involved in pyroptosis in the mouse MI heart. Our data showed that CLMP was strongly expressed in fibroblasts of the infarcted mouse hearts. The Clmp^+/- mice showed more serious myocardial fibrosis and ventricular dysfunction post-MI than wild-type (Clmp^+/+ ) mice, indicating a protective effect of the fibroblast-expressed CLMP against MI-induced heart damage. Transcriptome analyses by RNA sequencing indicated that Il-1β mRNA was significantly

SUBMITTER: Han X 

PROVIDER: S-EPMC7753842 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature