Cask methylation involved in the injury of insulin secretion function caused by interleukin1-β.

ABSTRACT: Islet inflammation severely impairs pancreatic β-cell function, but the specific mechanisms are still unclear. Interleukin1-β (IL-1β), an essential inflammatory factor, exerts a vital role in multiple physio-pathologic processes, including diabetes. Calcium/calmodulin-dependent serine protein kinase (CASK) is an important regulator especially in insulin secretion process. This study aims to unveil the function of CASK in IL-1β-induced insulin secretion dysfunction and the possible mechanism thereof. Islets of Sprague-Dawley (SD) rats and INS-1 cells stimulated with IL-1β were utilized as models of chronic inflammation. Insulin secretion function associated with Cask and DNA methyltransferases (DNMT) expression were assessed. The possible mechanisms of IL-1β-induced pancreatic β-cell dysfun

SUBMITTER: Wang TY 

PROVIDER: S-EPMC7753871 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature