Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial.

ABSTRACT:

Importance

Treatment of pediatric obesity is challenging. Preclinical studies in mice indicated that weight and metabolism can be altered by gut microbiome manipulation.

Objective

To assess efficacy of fecal microbiome transfer (FMT) to treat adolescent obesity and improve metabolism.

Design, setting, and participants

This randomized, double-masked, placebo-controlled trial (October 2017-March 2019) with a 26-week follow-up was conducted among adolescents aged 14 to 18 years with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 30 or more in Auckland, New Zealand. A total of 87 individuals took part-565 individuals responded to advertisements, 328 were ineligible, and 150 declined participation. Clinical data were analy

SUBMITTER: Leong KSW 

PROVIDER: S-EPMC7753902 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature