Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy.

ABSTRACT:

Background

In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected. However, the epileptic foci in a considerable percentage of the DRE patients cannot be adequately localised. This warrants the need for a reliable imaging strategy to identify the "concealed" epileptic regions.

Methods

Brain specimens from DRE patients and kainate-induced epileptic mouse models were immuno-stained to evaluate the integrity of the blood-brain barrier (BBB). The expression of low-density lipoprotein receptor-related protein-1 (LRP1) in the epileptic region of DRE patients and kainate models was studied by immunofluorescence. A micellar-based LRP1-targeted paramagnetic probe (Gd^3+<

SUBMITTER: Wang C 

PROVIDER: S-EPMC7753923 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature